The rise of genetic architecture
In science, like most things, one prefers simple over complex whenever possible. You keep adding variables until the explanatory juice starts hitting diminishing marginal returns. So cystic fibrosis is due to a mutation at one gene, and the disease exp…
Synthetic associations and all that
PLoS Biology has four items of great interest out today:
– Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results
– Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
– Th…