Sibling design or bust for polygenic risk scores
Unless you have been sleeping under a rock you are aware that there are lots of constant discussions about “polygenic risk scores” (PRS) and residual “population stratification.” The basic issue here is that when you have a risk profile generated by lots of smaller genetic effects that you sum up together the inference of those […]
Let the genomic die fly!
A new “polygenic risk score” (PRS) paper is making some waves, Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood. Since it is open access I suggest you read it. But basically, they took ~2 million common variants (there are about ~100 million common variants in the world population) in ~300,000 individuals in […]
Not happening at genomic speed: diversification of GWAS panels
One of the things that is evident and the norm when you are interested in genetics and genomics is that things happen fast. There are some sciences which proceed at a normal and conventional pace. But, because genomics is fundamentally driven by the …