Heterozygote advantage in resistance to tuberculosis
The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans:
Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A hypersusceptible […]