Category: Genomics
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Should we Invest in Curing Rare Diseases or Making Them Rarer?
An guest-post from Noor Siddiqui and Nikki Teran of Orchid Rare diseases cost Americans around 8 trillion dollars a year. About half of that is direct medical costs. If families are […]
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Dr. Amanda Vondras: standing on the shoulders of giants
https://medium.com/media/703b1c9872ad474e6f2037e17ac20c1b/hrefThis weekend Amandra Vondras, GenRAIT’s Director of Science, went on David McKay’s podcast, Standing on the Shoulders of Giants. She discussed her background as a molecular biologist, her pa…
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The age of forensic genomics
An age of forensic genomicsJoseph James DeAngeloThe Golden State Killer, a sinister figure who terrorized Californians between 1974 and 1986, was apprehended on April 24, 2018. This elusive predator, known by various monikers such as the East Area Rapi…
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70 years since Watson and Crick publish the structure of DNA
On April 25th, 1953, James Watson and Francis Crick published Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid. This paper helped Watson, Crick and Maurice Wilkins win the Nobel Prize in Medicine in 1962 (Rosalind Franklin…
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Introducing the GenRAIT Podcast
At the intersection of biology and technologyRecently we debuted the GenRAIT podcast, where we discuss the broad industry space that we aim to serve, the space where biology and technology merge together.You can listen to the podcasts at their dedicate…
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Precise medicine is accurate medicine
More than 40 years ago my mother got a shocking result in her yearly check-up when she was a new immigrant to the US: she had very high cholesterol. The doctors were perplexed, because she was thin and did not have a cholesterol-heavy diet (remember wh…
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Artificial intelligence and life science in the 21st century: chatGPT, genomics and the path…
Artificial intelligence and life science in the 21st century: chatGPT, genomics and the path forwardA query to ChatGPTUnless you’ve been sleeping under a rock, you’ve been reading about and experiencing how the new generation of artificial intelligence…
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CRISPR/Cas9: the genetic engineering century
If you were in and around genetics laboratories in the early 2010’s, one thing would be immediately apparent: CRISPR was going to revolutionize the field. Many research groups were shifting from their long-preferred genetic engineering techniques to th…
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Genomic data “eating the world”
What do we plan to do about it?Most of you have probably seen the NHGRI chart that illustrates the crash in the sequencing cost per human genome. To get some perspective, it cost $3 billion to sequence the first human genome over ten years in the year …
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GenRAIT goes to PAG 30
Furthering the life science data revolution in plant and animal genomicsRazib Khan, Taylor Capito, and Santanu Das at PAG 30During the second week of January 2023, the GenRAIT leadership team attended the Plant & Animal Genome Conference in San Die…
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The genetic future is here
In the year 2000, there was one single human genome. In 2010 there were fewer than 100 human genomes (you could look them up in a spreadsheet!). Today there are likely 1,000,000 human genomes. Good luck cataloging them all. Outside of the purview of our species, there are now efforts to sequence every animal on…
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The Data Platform for the Genomic Revolution
Introducing GenRAIT to the post-genomic eraThe human genetic map became reality in the first two decades of the 21st century. This was the dream of a century of genetics, laboriously tracing pedigrees across families decade after decade. But the combin…
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Nebula Genomics, 12-hour sale
It looks like Nebula Genomics has a 12-hour sale (as of this posting). This means you can get medical-grade 30x sequencing for $299. I do not recommend 100x because that […]
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The Genetic History of the Middle East: into Arabia
A new massive preprint on the Middle East is out. I’ve edited the first figure to give people a general sense of the broad results and populations sampled. First, you […]
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The Great Stagnation, genomics edition
Yaniv Erlich has been talking about the stability of the cost of sequencing for the last few years on Twitter. For what it’s worth, I think the stagnation is probably due to lack of competition. Illumina could surely move the price point further down through squeezing more efficiencies out of the process. In fact, they…
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Veritas’ price drop to $599
For many years friends have been asking me whole genome sequencing retail would be “cheap.” Well, as Emily Mullin reports, Veritas is now dropping their retail price to $599. You Can Now Get Your Whole Genome Sequenced for Less Than an iPhone: Veritas Genetics is making a big bet that people want to know what’s…
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Veritas’ price drop to $599
For many years friends have been asking me whole genome sequencing retail would be “cheap.” Well, as Emily Mullin reports, Veritas is now dropping their retail price to $599. You Can Now Get Your Whole Genome Sequenced for Less Than an iPhone: Veritas Genetics is making a big bet that people want to know what’s…
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Privacy in a social genomic age
I recently had a long conversation with Veritas Genetics’ Rodrigo Martinez for an episode of The Insight, our podcast on genetics and evolution. One of his major arguments is that we are entering into the age of the social genome.And the numbers don’t …
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Surfing into the genomic future
The decline in cost per genomeWithin genomics circles, the chart above illustrating the crash in sequencing costs since the year 2000 is famous. The reason it is famous is that it shows that genomic technology began to outrun the famous “Moore’s Law”, …
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In search of the missing heritability
We’ve always known that parents resemble their offspring. An intuitive understanding of how traits are passed down in families is probably as old as our species and its ability to reflect on the world around us. The ancient Romans would often observe a…