Batch effects in the 1000 Genomes data?
This is an important preprint, Legacy Data Confounds Genomics Studies: Recent reports have identified differences in the mutational spectra across human populations. While some of these reports have been replicated in other cohorts, most have been reported only in the 1000 Genomes Project (1kGP) data. While investigating an intriguing putative population stratification within the Japanese […]
Tightening the interval of the expected
The Pith: The rarer the genetic variant, the more likely that variant is to be specific to a distinct population. Including information about the distribution of these genetic variants missed in current techniques can increase greatly the precision of …
Ashkenazi 23andMe v3 genotype for the taking
Recently a friend got their 23andMe genotype results, and was wondering if there was something they could do for the “greater good.” I told him that he should throw his genotype out to the public domain and attach his name to it. For variou…
The layers and fault-lines of genes
At Genomes Unzipped Luke Jostins elaborates on how the genetic facts he now has about his paternal lineage change how he views his own personal history:
… my father’s father is Latvian, and the N1 haplogroup is not rare in the Baltic regions. In fact, the subgroup, N1c1, is more common in parts of Eastern Europe […]