Category Archives: Genetics

John Hawks illustrates what can be gained at the intersection of old data and analysis and new knowledge, Quote: Boyd on New World pigmentation clines:
I’m using some statistics out of William Boyd’s 1956 printing of Genetics and the Races of Man[1]. It gives a good accounting of blood group data known more than fifty years […]

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Dienekes has a pointer to a new paper on Gypsy genetics which surveys Y lineage variation among three Roma groups from Serbia in the context of Europe-wide Gypsy genetic variance, as well as their potential host (European) and source (Indian) populations. Since I recently posted on the topic, and Dienekes didn’t post some of the […]

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A month ago I pointed to a short communication in Nature Genetics which highlighted differences in the patterns of variation between the X chromosome and the autosome. I thought it would be of interest to revisit this, because it’s a relatively short piece with precise and crisp results which we can ruminate upon.
Sometimes there is […]

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With the recent huge furor over the utility of kin selection I’ve been keeping a closer eye on the literature on inclusive fitness. The reason W. D. Hamilton’s original papers in The Journal of Theoretical Biology are highly cited is not some conspiracy, rather, they’re a powerful framework in which one can understand the evolution […]

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I was browsing The European Journal of Human Genetics and I saw this short article from last summer which I missed, NordicDB: a Nordic pool and portal for genome-wide control data. The portal is at http://www.nordicdb.org/database/Home.html. The data itself is for Very Special People, instead of having a simple web form you actually have to […]

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100 years ago a science based physical anthropology offered up very little as to a systematics of mankind beyond what you could intuit from visual assessments of phenotypic similarity alone. Instead, there were fantastical taxonomies which had little basis in the true pattern of variation and more in the nationalistic debates of that period. The […]

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In the comments below a strange conversation grew out of the politicized nature of Pakistani identity, and its relationship to India the nation-state, and India the civilization. I assume that a typical reader, or more accurately commenter, on this weblog would be sanguine if they found out they were 10% chimpanzee. After all, it’s what’s […]

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An interesting readable review in PLoS Genetics taking on population genetics, Frail Hypotheses in Evolutionary Biology:
In conclusion, I return to Michael Lynch’s challenging questions about blind spots and bad wheels in evolutionary biology which motivated this review…Concerning blind spots I have pointed out some limitations of current population genetics. There is too much emphasis on […]

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If you live in the States one of the things you hear a lot about Europe in regards to its relationship to its ethno-religious minorities are the problems with Muslims. This is probably an Americo-centric perspective shaped by 9/11, when many of the hijackers had turned out to have spent time in Germany. Additionally, […]

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There’s a new paper out in The European Journal of Human Genetics which is of great interest because it surveys the genetic and linguistic affinities of two dozen ethno-linguistic groups from the three Central Asian nations of Uzbekistan, Kyrgyzstan, and Tajikistan. This is what the Greeks referred to as Transoxiana, and the Persians as […]

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Natural selection happens. It was hypothesized in copious detail by Charles Darwin, and has been confirmed in the laboratory, through observation, and also by inference via the methods of modern genomics. But science is more than broad brushes. We need to drill-down to a more fine-grained level to understand the dynamics with precision and detail, […]

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With all the justified concern about “missing heritability”, the age of human genomics hasn’t been a total bust. As I have observed before in 2005’s excellent book Mutants the evolutionary geneticist Armand M. Leroi asserted that we really didn’t have a good understanding of normal variation of human pigmentation. At the time I think it […]

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A few days ago I was listening to an interview with a reporter who was kidnapped in the tribal areas of Pakistan (he eventually escaped). Because he was a Westerner he mentioned offhand that to “pass” as a native for his own safety he had his guides claim he was Nuristani when inquiries were made. […]

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Last spring I posted ‘Beyond visualization of data in genetics’ in the hopes that people wouldn’t take PCA too far in assuming that the method was a reflection of reality in a definite fashion. Remember, PCA visualizations are showing you two, and at most three, dimensions in genetic variation within the data set at any […]

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When I talk about sexual selection I usually make sure to have an accompanying visual of a peacock to go with the post. But really I could have used a dandy as an illustration, or perhaps in our day & age “The Situation”. Unlike the peacock much of what passes for human “plumage” is not […]

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Sexual selection is, for lack of a better term, a sexy concept. Charles Darwin elaborated on the specific phenomenon of sexual selection in The Descent of Man, and Selection in Relation to Sex. In The Third Chimpanzee Jared Diamond endorsed Darwin’s thesis that sexual selection could explain the origin of human races, as each isolated […]

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Over the past decade evolutionary geneticist Mike Lynch has been articulating a model of genome complexity which relies on stochastic factors as the primary motive force by which genome size increases. The argument is articulated in a 2003 paper, and further elaborated in his book The Origins of Genome Architecture. There are several moving parts […]

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Last spring two very thorough papers came out which surveyed the genetic landscape of the Jewish people (my posts, Genetics & the Jews it’s still complicated, Genetics & the Jews). The novelty of the results was due to the fact that the research groups actually looked across the very diverse populations of the Diaspora, from […]

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A reader asked about the bizarre story of Adolf Hitler having “non-Aryan” ancestry. Specifically, The Daily Mail title is: “DNA tests reveal ‘Hitler was descended from the Jews and Africans he hated.’” Since it’s a British newspaper I frankly wouldn’t put it past them to simply pass along a hoax…but I think if they were going […]

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On the heels of my post on cousin marriage, I thought readers might find this article on genetic screening in the United Arab Emirates of interest. One way to tackle the problem of genetic diseases which emerge out of consanguineous unions apparently isn’t to discourage the unions themselves, but dodge the outcomes. So pre-implantation screening […]

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780/850
Razib Khan