My family’s Neandertal genes, ii
Last week I reported that it turns out that one of my siblings carry a possible Neandertal haplotype on the dystrophin gene. To review, it seems likely that ~3% of the average non-African’s genome is derived from Neandertal populations. But by an…
“Asian” in all the right places
mtDNA haplogroup G1a2
The pith: In this post I examine the most recent results from 23andMe for my family in the context of familial and regional (Bengal) history. I also use these results to offer up a framework for the ethnognesis of the eastern Ben…
Neandertal (haplotype) in the family!
There is pretty much a 100% probability that I carry Neandertal origin genes, since I’m Eurasian. That being said, I hadn’t looked too closely into the matter in regards to my own genome, because the whole “which SNPs are Neandertal&#…
Visualizing variation, input → output
I have noted a few times that one thing you have to be careful about in two dimensional plots which show genetic variance is that the dimensions in which the data are projected upon are often generated from the data itself. So adding more data can chan…
23andMe v3 chip & me
Yesterday the first batch of results from 23andMe’s v3 chip came online. Instead of 550,000 SNPs you get ~1 million. The difference is pretty clear when you look at the raw SNPs. Under Account → Browse Raw Data, I can enter LCT, and this is wha…
Reminder, 23andMe sale through Christmas
A reminder that 23andMe’s sale is valid until Christmas. Including the mandatory yearly subscription to their “Personal Genome Service”, that’s $160 (though you only get charged $99 + shipping initially, the subscription is $5/month). I didn’t quite go up to the 10 kits per person, but I did come close. There will likely be new […]
My Dodecad results
A few days ago Dienekes opened up the Dodecad project to a wider range of Eurasians. I decided to send my 23andMe sample to Dienekes ASAP, and the results came back today. I’m DOD075. Dienekes also just put up an explanation of the 10 ancestral components he’s generating from ADMIXTURE (along with tree-like representations of […]
The Dodecad ancestry project
Dienekes Pontikos, Introducing the Dodecad ancestry project:
1) Project goals
The Dodecad ancestry project has two goals:
– To provide detailed ancestry analysis to individuals who have tested with 23andMe; other testing companies may be included in the future.
– To build samples of individuals for regions of the world (e.g. Greeks, Finns, Albanians, Southern Italians, etc.) currently under-represented […]
The confusions of genetic relatedness
Last spring I posted ‘Beyond visualization of data in genetics’ in the hopes that people wouldn’t take PCA too far in assuming that the method was a reflection of reality in a definite fashion. Remember, PCA visualizations are showing you two, and at most three, dimensions in genetic variation within the data set at any […]
Personal genomics & the state
Dr. Daniel MacAthur & Dan Vorhaus offer their takes on the recent hearings in Congress on the direct-to-consumer genomics industry, A sad day for personal genomics & “From Gulf Oil to Snake Oil”: Congress Takes Aim at DTC Genetic Testing. I guess I lean toward light regulation. I don’t think that DTC personal genomics will […]
Creative destruction in the personal genomics industry?
I’m hearing about rumblings at 23andMe, and not in a good way. The company made a big splash a few years ago, and came highly recommended by friends (e.g., “They know their science, and have a bottomless pool of money”). This story at BNET got my attention though, and confirmed what many have been […]