I got a notification today from Ian Logan that he set up a page on my genotype using a method which detects rare homozygous SNPs in the ~1 million markers I put up from my 23andMe results. My raw data is online, so anyone can analyze it. Here is the summary of my results:
The program finds about 50 ‘rare/uncommon’ SNPs from the 900,000+ tested by 23andMe.
The are no ‘homozygous-recessive’ results (surprisingly, as 1-2 might be expected).
There are a list other individuals, and sure enough most of them do have a rare recessive homozygous locus or two. I assume that ascertainment bias (the technology finding variation in Europeans better than non-Europeans in most cases) wouldn’t result in my case, because I should have less variation, not more (less variation would presumably result in more homozygous recessives). So I am thinking it may simply be that because I’m from a population with greater genetic variation (South Asians) I am less likely to yield a homozygous recessive.
In most cases population substructure doesn’t yield benefits for South Asians in terms of their genetic variation, because of intra-caste marriage (so the useful scope of ‘population’ is much smaller than the geographic one), …