23andMe v3 chip & me

23andMe v3 chip & me

Yesterday the first batch of results from 23andMe’s v3 chip came online. Instead of 550,000 SNPs you get ~1 million. The difference is pretty clear when you look at the raw SNPs. Under Account → Browse Raw Data, I can enter LCT, and this is what I see:

I’m line #2. A sibling is line #1. Looking at this sort of stuff makes it really likely I’ll upgrade. My main rationale for not upgrading is that there’s diminishing marginal returns for ancestry related stuff. Speaking of ancestry, let’s compare my sibling’s ancestry painting to my own.

In a bit of a surprise, while I’m 43% “Asian,” my sibling is 40% “Asian.” This is somewhat reflected in global similarity.

Razib
Sibling
Difference

Northern Europe
66.56
66.53
0.03

Southern Europe
66.47
66.43
0.04

Middle Eastern
66.38
66.35
0.03

Northern Africa
65.78
65.68
0.1

Central/South Asia
67.18
67.14
0.04

East Asia
67.66
67.56
0.1

Siberia
67.47
67.36
0.11

Oceania
67.39
67.32
0.07

North America
67.2
67.15
0.05

South America
67.33
67.18
0.15

West African
63.99
63.87
0.12

Central African
64
63.89
0.11

Eastern African
64.15
64.06
0.09

South African
64.04
63.93
0.11

I was curious if the differences were v3 vs. v2 chip, so I compared two individuals of Northern European ancestry:

Northern Europe v2
Northern Europe v3
Difference

Northern Europe
67.82
67.88
-0.06

Southern Europe
67.74
67.73
0.01

Middle Eastern
67.14
67.12
0.02

Northern Africa
66.42
66.37
0.05

Central/South Asia
66.88
66.94
-0.06

East Asia
65.73
65.77
-0.04

Siberia
66.05
66.07
-0.02

Oceania
65.62
65.74
-0.12

North America
66.11
66.15
-0.04

South America
66.01
66.02
-0.01

West African
63.29
63.21
0.08

Central African
63.35
64.24
-0.89

Eastern African
63.48
63.43
0.05

South African
63.37
63.27
0.1

There’s less of a consistent difference here. So I really don’t know what to think.

Razib Khan